C2CD3

Across TCGA patient cohorts, C2CD3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2CD3-associated genes across cancer lineages are GAPDH, 14-3-3_beta, and Heregulin. Each is linked with C2CD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both C2CD3-to-partner and partner-to-C2CD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by C2CD3-low versus C2CD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2CD3→partner) and Y-score (partner→C2CD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.346	+1.700	.038	.040	3	3
LUSC	14-3-3_beta →	-0.122	-3.160	.034	.019	3	2
LUAD	Heregulin →	-0.140	-3.000	.034	.035	3	2
LUAD	MYH11 →	-1.156	-2.321	.006	.035	3	2
LUAD	PKC-a →	-0.254	-2.321	.037	.035	3	2
LUAD	Rictor_pT1135 →	+0.183	+2.321	.003	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

GAPDH by C2CD3 expression — UCEC

Explore this box plot interactively →