C2CD2L

Across TCGA patient cohorts, C2CD2L mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2CD2L-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and PCNA. Each is linked with C2CD2L in more than 2 cancer types. Because this analysis shows association rather than direction, both C2CD2L-to-partner and partner-to-C2CD2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by C2CD2L-low versus C2CD2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2CD2L→partner) and Y-score (partner→C2CD2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.851	+3.906	<.001	<.001	3	3
UCEC	eEF2 →	+0.359	+2.999	.021	.035	3	2
UCEC	PCNA →	+0.231	+2.807	.014	.003	3	2
UCEC	Annexin-1 →	+0.639	+2.115	.005	.019	3	2
UCEC	14-3-3_beta →	-0.105	-3.143	.017	.018	3	1
UCEC	EGFR_pY1068 →	-0.256	-2.115	.019	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by C2CD2L expression — UCEC

Explore this box plot interactively →