C2CD2

Across TCGA patient cohorts, C2CD2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2CD2-associated genes across cancer lineages are FOXO3a_pS318_S321, Rictor_pT1135, and Shc_pY317. Each is linked with C2CD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2CD2-to-partner and partner-to-C2CD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by C2CD2-low versus C2CD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2CD2→partner) and Y-score (partner→C2CD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.134	-2.896	.003	.001	3	2
UCEC	Rictor_pT1135 →	-0.104	-3.459	.005	.005	3	2
UCEC	Shc_pY317 →	-0.197	-3.807	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.383	-1.668	<.001	.021	3	2
UCEC	VHL →	-0.930	-1.847	<.001	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.857	+2.242	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

FOXO3a_pS318_S321 by C2CD2 expression — UCEC

Explore this box plot interactively →