Across TCGA cell cohorts, C22orf42 mutation is significantly associated with the mutation status of many other genes, with 1,441 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C22orf42-associated genes across cancer lineages are PCDHGC3, AGO1, and NLRP14. Each is linked with C22orf42 in more than 2 cancer types. Because this analysis shows association rather than direction, both C22orf42-to-partner and partner-to-C22orf42 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf42→partner) and Y-score (partner→C22orf42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PCDHGC3 →	+4.239	+5.053	.007	.007	1	3
LUNG_NSCLC_LUAD	AGO1 →	+5.772	+5.772	.002	.002	1	3
LUNG_NSCLC_LUAD	NLRP14 →	+4.187	+5.000	.008	.008	1	3
SKIN	PLA2G3 →	+5.824	+5.824	.002	.002	1	3
LARGE_INTESTINE	ZBTB40 →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	LY75-CD302 →	+3.087	+4.392	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,441 associations by consensus.

Exploration

C22orf42 survival (RNA) · tumor vs normal (RNA) · all C22orf42 data types