Across TCGA patient cohorts, C21orf62 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C21orf62-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and eIF4G. Each is linked with C21orf62 in more than 1 cancer types. Because this analysis shows association rather than direction, both C21orf62-to-partner and partner-to-C21orf62 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C21orf62→partner) and Y-score (partner→C21orf62) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.253	-2.415	.012	.003	3	1
UCEC	eIF4E →	+0.222	+2.415	.008	.003	3	1
UCEC	eIF4G →	+0.305	+2.999	.014	.035	3	1
UCEC	A-Raf_pS299 →	-0.143	-3.459	.002	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.135	-2.797	.007	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.266	-3.074	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

C21orf62 survival (RNA) · tumor vs normal (RNA) · all C21orf62 data types