C21orf58

Across TCGA patient cohorts, C21orf58 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,124 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C21orf58-associated proteins across cancer lineages are MCM3, FEN1, and LIG1. Each is linked with C21orf58 in more than 8 cancer types. Because this analysis shows association rather than direction, both C21orf58-to-partner and partner-to-C21orf58 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C21orf58 versus MCM3 in GBM, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C21orf58→partner) and Y-score (partner→C21orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM3 →	+0.823	+0.911	<.001	<.001	3	9
LSCC	FEN1 →	+0.534	+0.814	<.001	<.001	3	8
BRCA	LIG1 →	+0.481	+0.732	<.001	<.001	3	8
GBM	MCM2 →	+0.779	+0.911	<.001	<.001	3	8
LUAD	MCM2_S41 →	+0.733	+0.669	<.001	<.001	3	8
LSCC	CHTF18_S871 →	+0.614	+0.698	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,124 associations by consensus.

C21orf58 vs MCM3 — GBM

Explore this scatter interactively →