C20orf144

Across TCGA pan-cancer cohorts, C20orf144 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of C20orf144’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C20orf144 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C20orf144 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where C20orf144 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C20orf144 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.416	<.001	11	view →
COAD	Male	All	+0.519	<.001	10	view →
BLCA	Male	All	+0.507	<.001	10	view →
LIHC	Female	All	+0.157	<.001	8	view →
STAD	Male	II,III,IV	+0.460	<.001	7	view →
LUSC	Male	II,III,IV	+0.435	<.001	7	view →
LUAD	Male	All	+0.424	<.001	7	view →
READ	All	III,IV	+0.414	<.001	7	view →
BRCA	All	All	+0.359	<.001	6	view →
UCEC	All	All	+0.315	<.001	6	view →
KIRC	Male	II,III,IV	−0.104	.001	6	view →
THCA	All	All	−0.099	.020	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

C20orf144–HNSC

Open the HNSC breakdown →