C20orf141

Across TCGA pan-cancer cohorts, C20orf141 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of C20orf141’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C20orf141 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C20orf141 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where C20orf141 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C20orf141 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.734	<.001	12	view →
KIRC	All	All	+0.106	.001	8	view →
LUAD	All	All	+0.211	<.001	7	view →
LUSC	All	All	+0.256	.002	5	view →
KIRP	All	All	+0.390	.006	4	view →
COAD	All	II,III,IV	+0.043	.005	4	view →
UCEC	All	All	−0.310	.009	2	view →
BRCA	All	II,III,IV	+0.087	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

C20orf141–HNSC

Open the HNSC breakdown →