C2

Across TCGA pan-cancer cohorts, C2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C2 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, LUAD, and UCEC are the cancer types where C2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.910	1.000	.011	54	view →
LUAD	OS	Quartile	III,IV	0.134	0.840	.001	31	view →
UCEC	DFS	Quartile	All	0.730	0.971	.010	28	view →
LSCC	DFS	Quartile	II,III,IV	0.732	1.000	.003	22	view →
CCRCC	DFS	Median	All	0.888	0.623	.003	21	view →
GBM	OS	Quartile	All	0.233	0.563	.017	11	view →
HNSC	OS	Quartile	All	0.931	1.000	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C2–COAD (DFS)

Open the COAD breakdown →