C2

Across TCGA patient cohorts, C2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2-associated genes across cancer lineages are JNK2, Bax, and 4E-BP1_pS65. Each is linked with C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2-to-partner and partner-to-C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by C2-low versus C2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2→partner) and Y-score (partner→C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.233	+3.000	.043	.037	3	1
UCEC	Bax →	+0.321	+3.000	.020	.037	3	1
UCEC	4E-BP1_pS65 →	-0.237	-2.986	.036	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+0.795	+2.827	.020	.035	3	1
SKCM	c-Kit →	-0.766	-3.000	.041	.036	2	1
UCEC	EGFR_pY1068 →	-0.319	-3.000	.028	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK2 by C2 expression — UCEC

Explore this box plot interactively →