C2

Across TCGA cell cohorts, C2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,664 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible C2-associated GO terms across cancer lineages are Complement activation, classical pathway, Fatty acid catabolic process, and Monocarboxylic acid catabolic process. Each is linked with C2 in more than 10 cancer types. Because this analysis shows association rather than direction, both C2-to-partner and partner-to-C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation, classical pathway grouped by C2-low versus C2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C2→partner) and Y-score (partner→C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Complement activation, classical pathway →	+1.882	+4.691	<.001	<.001	3	11
LIVER	Fatty acid catabolic process →	+0.083	+3.576	.003	<.001	3	11
LIVER	Monocarboxylic acid catabolic process →	+0.085	+3.836	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of respiratory burst involved in inflammatory response →	+0.073	+1.133	.001	<.001	2	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of respiratory burst →	+0.073	+1.133	.001	<.001	2	11
OESOPHAGUS	Protein quality control for misfolded or incompletely synthesized proteins →	+0.074	+1.029	.001	.007	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,664 associations by consensus.

Complement activation, classical pathway by C2 expression — LIVER

Explore this box plot interactively →