C1orf94

Across TCGA patient cohorts, C1orf94 mutation is significantly associated with the RNA expression of many other genes, with 2,090 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf94-associated genes across cancer lineages are IFRD1, FAM177A1, and SKA1. Each is linked with C1orf94 in more than 2 cancer types. Because this analysis shows association rather than direction, both C1orf94-to-partner and partner-to-C1orf94 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFRD1 grouped by C1orf94-low versus C1orf94-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf94→partner) and Y-score (partner→C1orf94) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IFRD1 →	+0.629	+3.596	.007	.001	3	3
UCEC	FAM177A1 →	+0.317	+2.202	<.001	.001	3	3
UCEC	SKA1 →	+0.520	+2.436	.001	.001	3	3
UCEC	MOCS2 →	+0.317	+1.658	.003	.001	3	3
UCEC	GFM2 →	+0.525	+1.637	<.001	.001	3	3
SKCM	PPP2R2D →	+0.298	+3.932	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,090 associations by consensus.

IFRD1 by C1orf94 expression — LUAD

Explore this box plot interactively →