C1orf74

Across TCGA patient cohorts, C1orf74 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf74-associated genes across cancer lineages are TIGAR, GAPDH, and Heregulin. Each is linked with C1orf74 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf74-to-partner and partner-to-C1orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by C1orf74-low versus C1orf74-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf74→partner) and Y-score (partner→C1orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.151	+3.486	.048	.002	3	2
UCEC	GAPDH →	+0.732	+2.321	.006	.035	3	1
UCEC	Heregulin →	-0.147	-3.169	.018	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.231	-3.000	.006	.036	3	1
UCEC	mTOR_pS2448 →	-0.227	-3.156	.002	.018	3	1
UCEC	Myosin-IIa_pS1943 →	+0.233	+2.335	.024	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

TIGAR by C1orf74 expression — UCEC

Explore this box plot interactively →