C1orf74

Across TCGA cell cohorts, C1orf74 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,980 significant associations in total. BONE shows the largest number of these associations.

The most reproducible C1orf74-associated GO terms across cancer lineages are RNA 3'-end processing, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, and Establishment of protein localization to endoplasmic reticulum membrane. Each is linked with C1orf74 in more than 12 cancer types. Because this analysis shows association rather than direction, both C1orf74-to-partner and partner-to-C1orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA 3'-end processing grouped by C1orf74-low versus C1orf74-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf74→partner) and Y-score (partner→C1orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNA 3'-end processing →	+0.073	+0.688	<.001	<.001	3	13
LARGE_INTESTINE	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.132	+0.480	.001	<.001	3	13
LUNG_NSCLC_LUSC	Establishment of protein localization to endoplasmic reticulum membrane →	+0.154	+1.084	<.001	<.001	3	12
LUNG_NSCLC_LUSC	mRNA 3'-end processing →	+0.089	+0.617	<.001	.003	3	11
SOFT_TISSUE	RNA stabilization →	+0.079	+0.511	<.001	<.001	3	11
BONE	Nuclear pore organization →	+0.160	+0.484	.002	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,980 associations by consensus.

RNA 3'-end processing by C1orf74 expression — PANCREAS

Explore this box plot interactively →