C1orf54

Across TCGA patient cohorts, C1orf54 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf54-associated genes across cancer lineages are PLSCR5-AS1, OR10A3, and OR4K17. Each is linked with C1orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf54-to-partner and partner-to-C1orf54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLSCR5-AS1 grouped by C1orf54-low versus C1orf54-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf54→partner) and Y-score (partner→C1orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PLSCR5-AS1 →	+0.084	+7.640	<.001	.009	3	1
UCEC	OR10A3 →	+0.123	+3.599	<.001	.007	3	1
UCEC	OR4K17 →	+0.054	+4.335	.009	.007	3	1
UCEC	RPL31P9 →	+0.334	+4.453	<.001	.006	3	1
UCEC	MIR4659A →	+0.717	+3.418	<.001	.009	3	1
UCEC	RN7SL510P →	+0.351	+3.957	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PLSCR5-AS1 by C1orf54 expression — BLCA

Explore this box plot interactively →