C1orf54

Across TCGA cell cohorts, C1orf54 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,993 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C1orf54-associated GO terms across cancer lineages are Regulation of macroautophagy, CENP-A containing chromatin assembly, and Meiotic chromosome segregation. Each is linked with C1orf54 in more than 8 cancer types. Because this analysis shows association rather than direction, both C1orf54-to-partner and partner-to-C1orf54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by C1orf54-low versus C1orf54-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf54→partner) and Y-score (partner→C1orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of macroautophagy →	+0.044	+0.884	<.001	.005	3	9
PANCREAS	CENP-A containing chromatin assembly →	-0.133	-0.899	.001	.001	3	7
PANCREAS	Meiotic chromosome segregation →	-0.135	-0.927	<.001	<.001	3	7
BLOOD_Myeloma	Cellular response to chemical stress →	+0.030	+1.108	.003	<.001	3	6
OESOPHAGUS	Immunoglobulin heavy chain V-D-J recombination →	-0.216	-0.796	.002	.008	3	6
BONE	Regulation of mitotic spindle checkpoint →	-0.129	-2.436	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,993 associations by consensus.

Regulation of macroautophagy by C1orf54 expression — URINARY_TRACT

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