Across TCGA pan-cancer cohorts, C1orf53 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated C1orf53 data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher C1orf53 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1orf53 expression acts as an unfavorable survival marker.

THCA and SKCM are the cancer types where C1orf53 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.133	0.842	.001	12	view →
SKCM	OS	Median	All	0.179	0.781	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: C1orf53 tumor-vs-normal RNA expression · all C1orf53 data types