Across TCGA pan-cancer cohorts, C1orf53 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C1orf53 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C1orf53 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C1orf53 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where C1orf53 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	1.000	0.818	.006	30	view →
PDAC	OS	Tertile	III,IV	0.277	0.813	.024	6	view →
LUAD	DFS	Tertile	III,IV	0.357	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: C1orf53 tumor-vs-normal RNA expression · all C1orf53 data types