Across TCGA pan-cancer cohorts, C1orf53 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of C1orf53’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where C1orf53 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C1orf53 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LUAD, CCRCC, and PDAC are the cancer types where C1orf53 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf53 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+1.475	<.001	8	view →
CCRCC	All	All	−0.780	<.001	8	view →
PDAC	Male	All	+1.622	.006	4	view →
LSCC	Male	All	+0.460	.008	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: C1orf53 RNA expression & survival · all C1orf53 data types