Across TCGA patient cohorts, C1orf53 protein abundance is significantly associated with the RNA expression of many other genes, with 2,328 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C1orf53-associated genes across cancer lineages are SIX4, MAP3K9, and GRB14. Each is linked with C1orf53 in more than 2 cancer types. Because this analysis shows association rather than direction, both C1orf53-to-partner and partner-to-C1orf53 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf53→partner) and Y-score (partner→C1orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SIX4 →	+1.137	+0.770	.001	.002	3	3
LSCC	MAP3K9 →	+0.772	+0.594	<.001	<.001	3	3
BRCA	GRB14 →	+2.395	+1.334	.002	<.001	3	2
BRCA	TOX3 →	-1.838	-1.164	.003	.005	3	2
PDAC	PPP4R4 →	+1.151	+0.931	.004	.003	3	2
BRCA	UBR1 →	-1.008	-1.355	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,328 associations by consensus.

Exploration

C1orf53 survival (RNA) · tumor vs normal (RNA) · all C1orf53 data types