C1orf52

Across TCGA pan-cancer cohorts, C1orf52 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C1orf52 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher C1orf52 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C1orf52 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, UCEC, and PDAC are the cancer types where C1orf52 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.854	0.421	.011	11	view →
UCEC	DFS	Tertile	II,III,IV	0.904	0.435	.037	8	view →
PDAC	OS	Median	II,III,IV	0.749	0.951	.040	6	view →
HNSC	OS	Median	II,III,IV	1.000	0.953	.019	6	view →
CCRCC	DFS	Median	II,III,IV	0.844	0.389	.004	6	view →
LSCC	DFS	Quartile	All	0.962	0.871	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C1orf52–LUAD (DFS)

Open the LUAD breakdown →