C1orf52

Across TCGA patient cohorts, C1orf52 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf52-associated genes across cancer lineages are JNK2, Ku80, and MEK1. Each is linked with C1orf52 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf52-to-partner and partner-to-C1orf52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by C1orf52-low versus C1orf52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf52→partner) and Y-score (partner→C1orf52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.241	+3.459	.015	.005	3	1
UCEC	Ku80 →	+0.290	+3.009	.014	.019	3	1
UCEC	MEK1 →	+0.362	+3.169	.049	.019	3	1
UCEC	p62 Lck ligand →	+0.360	+2.321	.027	.035	1	1
UCEC	TFRC →	+0.701	+2.321	.008	.035	1	1
UCEC	Caspase-8 →	-0.281	-3.459	.026	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by C1orf52 expression — UCEC

Explore this box plot interactively →