C1orf52

Across TCGA cell cohorts, C1orf52 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C1orf52-associated genes across cancer lineages are SEPTIN14, ITGAD, and NPY2R. Each is linked with C1orf52 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf52-to-partner and partner-to-C1orf52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14 grouped by C1orf52-low versus C1orf52-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf52→partner) and Y-score (partner→C1orf52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEPTIN14 →	+0.011	+4.684	<.001	.002	3	1
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	NPY2R →	+0.007	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	BPIFA1 →	+0.287	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SEPTIN14 by C1orf52 expression — LARGE_INTESTINE

Explore this box plot interactively →