C1orf43

Across TCGA patient cohorts, C1orf43 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf43-associated genes across cancer lineages are Ku80, AMPK_pT172, and Caspase-8. Each is linked with C1orf43 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf43-to-partner and partner-to-C1orf43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by C1orf43-low versus C1orf43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf43→partner) and Y-score (partner→C1orf43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.286	+3.335	.021	.005	3	1
UCEC	AMPK_pT172 →	+0.512	+3.335	.017	.005	3	1
UCEC	Caspase-8 →	-0.322	-2.973	.014	.035	3	1
UCEC	4E-BP1 →	+0.387	+3.029	.006	.018	3	1
UCEC	Di-Ras3 →	-0.207	-3.321	.007	.010	2	1
UCEC	EGFR_pY1068 →	-0.326	-3.321	.013	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by C1orf43 expression — UCEC

Explore this box plot interactively →