C1orf43

Across TCGA cell cohorts, C1orf43 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,575 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible C1orf43-associated GO terms across cancer lineages are Protein targeting to Golgi apparatus, Negative regulation of CD8-positive, alpha-beta T cell differentiation, and Blood coagulation, intrinsic pathway. Each is linked with C1orf43 in more than 12 cancer types. Because this analysis shows association rather than direction, both C1orf43-to-partner and partner-to-C1orf43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to Golgi apparatus grouped by C1orf43-low versus C1orf43-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf43→partner) and Y-score (partner→C1orf43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Protein targeting to Golgi apparatus →	+0.184	+0.804	<.001	<.001	3	13
OESOPHAGUS	Negative regulation of CD8-positive, alpha-beta T cell differentiation →	+0.229	+0.783	.001	.002	3	12
BREAST	Blood coagulation, intrinsic pathway →	-0.327	-0.973	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Endodermal cell differentiation →	-0.194	-0.717	.008	.006	3	9
BONE	Threonyl-tRNA aminoacylation →	+0.176	+0.884	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Regulation of heart rate by chemical signal →	-0.239	-0.629	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,575 associations by consensus.

Protein targeting to Golgi apparatus by C1orf43 expression — PANCREAS

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