C1orf226

Across TCGA patient cohorts, C1orf226 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf226-associated genes across cancer lineages are EGFR_pY1068, JNK2, and LKB1. Each is linked with C1orf226 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf226-to-partner and partner-to-C1orf226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C1orf226-low versus C1orf226-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf226→partner) and Y-score (partner→C1orf226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.291	-2.000	.010	.032	3	1
UCEC	JNK2 →	+0.309	+2.000	<.001	.032	3	1
UCEC	LKB1 →	-0.120	-3.169	.012	.019	3	1
UCEC	MEK1 →	+0.363	+2.459	.027	.019	3	1
UCEC	p62 Lck ligand →	+0.467	+3.807	.001	<.001	3	1
UCEC	PKC-delta_pS664 →	-0.128	-3.169	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by C1orf226 expression — UCEC

Explore this box plot interactively →