C1orf226

Across TCGA cell cohorts, C1orf226 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,309 significant associations in total. BONE shows the largest number of these associations.

The most reproducible C1orf226-associated GO terms across cancer lineages are Regulation of membrane repolarization during cardiac muscle cell action potential, Regulation of heart rate by chemical signal, and Regulation of myoblast fusion. Each is linked with C1orf226 in more than 13 cancer types. Because this analysis shows association rather than direction, both C1orf226-to-partner and partner-to-C1orf226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of membrane repolarization during cardiac muscle cell action potential grouped by C1orf226-low versus C1orf226-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf226→partner) and Y-score (partner→C1orf226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of membrane repolarization during cardiac muscle cell action potential →	-0.281	-2.409	<.001	<.001	3	14
BONE	Regulation of heart rate by chemical signal →	-0.484	-2.269	<.001	<.001	3	10
BREAST	Regulation of myoblast fusion →	+0.084	+1.735	<.001	<.001	3	9
LUNG_SCLC	Oxidative phosphorylation →	+0.087	+1.497	.002	<.001	3	8
BONE	ATP biosynthetic process →	+0.097	+1.994	.001	.008	3	8
BLOOD_Leukemia	Aerobic respiration →	+0.044	+0.789	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,309 associations by consensus.

Regulation of membrane repolarization during cardiac muscle cell action potential by C1orf226 expression — BONE

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