C1orf216

Across TCGA patient cohorts, C1orf216 protein abundance is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C1orf216-associated genes across cancer lineages are NME5, PCLAF, and DHCR7. Each is linked with C1orf216 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf216-to-partner and partner-to-C1orf216 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1orf216 versus NME5 in GBM, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf216→partner) and Y-score (partner→C1orf216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NME5 →	+1.666	+0.329	.009	.008	3	1
GBM	PCLAF →	-0.581	-0.246	.008	.005	3	1
GBM	DHCR7 →	+1.336	+0.329	.002	.008	3	1
GBM	NUPR1 →	-0.826	-0.329	.002	.008	3	1
GBM	PPIAP73 →	-0.918	-0.246	.005	.005	3	1
GBM	FBXO47 →	-0.150	-0.246	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

C1orf216 vs NME5 — GBM

Explore this scatter interactively →