C1orf198

Across TCGA pan-cancer cohorts, C1orf198 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C1orf198 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C1orf198 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C1orf198 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, LUSC, and GBM are the cancer types where C1orf198 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.199	0.756	.003	18	view →
LUSC	OS	Median	All	0.164	0.776	.003	12	view →
GBM	OS	Median	All	0.104	0.415	.024	3	view →
SKCM	DFS	Median	All	0.810	0.196	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C1orf198–HNSC (OS)

Open the HNSC breakdown →