C1orf198

Across TCGA patient cohorts, C1orf198 mutation is significantly associated with the RNA expression of many other genes, with 1,360 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf198-associated genes across cancer lineages are MIR8053, IL21, and MTND4LP19. Each is linked with C1orf198 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf198-to-partner and partner-to-C1orf198 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by C1orf198-low versus C1orf198-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf198→partner) and Y-score (partner→C1orf198) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	MIR8053 →	+0.680	+5.152	<.001	.003	3	2
UCEC	IL21 →	+0.108	+1.586	<.001	.002	3	2
UCEC	MTND4LP19 →	+0.118	+2.136	<.001	.006	3	2
UCEC	RPL34P3 →	+0.080	+1.996	.007	.002	3	2
UCEC	RNA5SP421 →	+0.375	+1.796	.007	<.001	3	2
BLCA	FAM197Y5 →	+0.054	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,360 associations by consensus.

MIR8053 by C1orf198 expression — SARC

Explore this box plot interactively →