C1orf198

Across TCGA patient cohorts, C1orf198 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf198-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and A-Raf_pS299. Each is linked with C1orf198 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf198-to-partner and partner-to-C1orf198 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by C1orf198-low versus C1orf198-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf198→partner) and Y-score (partner→C1orf198) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.088	-1.489	.017	.030	3	1
UCEC	eIF4E →	+0.268	+2.736	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.135	-2.459	.002	.019	3	1
UCEC	GATA6 →	-0.155	-2.222	.006	.010	3	1
UCEC	MSH2 →	-0.301	-3.295	<.001	.009	3	1
UCEC	MSH6 →	-0.358	-1.690	.003	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

14-3-3_beta by C1orf198 expression — UCEC

Explore this box plot interactively →