Across TCGA pan-cancer cohorts, C1orf174 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C1orf174 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C1orf174 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1orf174 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where C1orf174 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.477	0.831	.002	27	view →
LUAD	DFS	Median	All	0.892	0.432	.001	17	view →
PDAC	DFS	Quartile	All	0.472	0.273	.018	12	view →
OV	DFS	Median	All	1.000	0.867	.035	4	view →
CCRCC	OS	Median	All	0.777	0.896	.040	3	view →
LSCC	OS	Tertile	All	1.000	0.781	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: C1orf174 tumor-vs-normal RNA expression · all C1orf174 data types