C1orf159

Across TCGA patient cohorts, C1orf159 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf159-associated genes across cancer lineages are Chk2, ERK2, and JNK2. Each is linked with C1orf159 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf159-to-partner and partner-to-C1orf159 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2 grouped by C1orf159-low versus C1orf159-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf159→partner) and Y-score (partner→C1orf159) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2 →	-0.273	-3.000	.026	.036	3	2
UCEC	ERK2 →	+0.318	+3.321	.001	.010	3	1
UCEC	JNK2 →	+0.368	+3.321	<.001	.010	3	1
UCEC	Notch1 →	+0.181	+3.321	.014	.010	3	1
UCEC	PEA-15_pS116 →	+0.513	+3.321	.005	.010	3	1
UCEC	VEGFR2 →	+0.319	+3.335	.041	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Chk2 by C1orf159 expression — UCEC

Explore this box plot interactively →