C1orf159

Across TCGA cell cohorts, C1orf159 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible C1orf159-associated genes across cancer lineages are SPINK9, USP17L3, and TMEM114. Each is linked with C1orf159 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf159-to-partner and partner-to-C1orf159 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by C1orf159-low versus C1orf159-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf159→partner) and Y-score (partner→C1orf159) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPINK9 →	+0.065	+5.415	<.001	.004	3	1
SKIN	USP17L3 →	+0.013	+5.415	<.001	.004	3	1
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1
LUNG_SCLC	SMCP →	+0.047	+4.643	<.001	.004	3	1
LUNG_SCLC	OR52B4 →	+0.017	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SPINK9 by C1orf159 expression — SKIN

Explore this box plot interactively →