Across TCGA patient cohorts, C1orf141 mutation is significantly associated with the RNA expression of many other genes, with 4,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf141-associated genes across cancer lineages are TEDC2, PLEKHH3, and E2F1. Each is linked with C1orf141 in more than 2 cancer types. Because this analysis shows association rather than direction, both C1orf141-to-partner and partner-to-C1orf141 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf141→partner) and Y-score (partner→C1orf141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TEDC2 →	+0.647	+2.721	<.001	<.001	3	3
UCEC	PLEKHH3 →	+0.620	+2.711	<.001	<.001	3	3
UCEC	E2F1 →	+0.897	+2.332	<.001	<.001	3	3
UCEC	MDC1 →	+0.800	+2.700	<.001	<.001	3	3
UCEC	FANCA →	+0.905	+3.807	<.001	<.001	3	3
UCEC	DCP1A →	+0.669	+2.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,586 associations by consensus.

Exploration

C1orf141 survival (RNA) · tumor vs normal (RNA) · all C1orf141 data types