C1orf131

Across TCGA patient cohorts, C1orf131 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf131-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Ku80. Each is linked with C1orf131 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf131-to-partner and partner-to-C1orf131 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C1orf131-low versus C1orf131-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf131→partner) and Y-score (partner→C1orf131) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.278	-2.000	.009	.029	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-3.321	.009	.010	3	1
UCEC	Ku80 →	+0.225	+1.713	.025	.027	3	1
UCEC	mTOR_pS2448 →	-0.163	-2.565	.009	.010	3	1
UCEC	NF-kB-p65_pS536 →	-0.402	-1.990	.037	.030	3	1
UCEC	PCNA →	+0.202	+2.906	.027	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by C1orf131 expression — UCEC

Explore this box plot interactively →