Across TCGA pan-cancer cohorts, C1orf122 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C1orf122 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C1orf122 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C1orf122 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where C1orf122 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.659	0.994	<.001	36	view →
PDAC	DFS	Median	All	0.200	0.372	.002	13	view →
UCEC	DFS	Median	II,III,IV	0.870	0.545	.043	4	view →
LUAD	DFS	Quartile	III,IV	0.760	0.254	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: C1orf122 tumor-vs-normal RNA expression · all C1orf122 data types