C1orf116

Across TCGA patient cohorts, C1orf116 mutation is significantly associated with the RNA expression of many other genes, with 3,413 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf116-associated genes across cancer lineages are MIR549A, CRYBB2P1, and POLDIP3. Each is linked with C1orf116 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf116-to-partner and partner-to-C1orf116 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR549A grouped by C1orf116-low versus C1orf116-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf116→partner) and Y-score (partner→C1orf116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR549A →	+0.307	+4.147	<.001	.009	3	2
UCEC	CRYBB2P1 →	+0.437	+2.385	.001	.002	3	2
UCEC	POLDIP3 →	+0.576	+2.244	<.001	<.001	3	2
UCEC	MCAT →	+0.353	+3.815	.002	<.001	3	2
UCEC	PHF5A →	+0.564	+3.700	<.001	<.001	3	2
SKCM	DESI1 →	+0.391	+3.274	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,413 associations by consensus.

MIR549A by C1orf116 expression — BLCA

Explore this box plot interactively →