C1orf116

Across TCGA patient cohorts, C1orf116 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf116-associated genes across cancer lineages are PDCD4, eEF2, and EGFR_pY1068. Each is linked with C1orf116 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf116-to-partner and partner-to-C1orf116 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by C1orf116-low versus C1orf116-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf116→partner) and Y-score (partner→C1orf116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.436	-1.874	.010	.049	3	2
UCEC	eEF2 →	+0.307	+2.459	.017	.018	3	1
UCEC	EGFR_pY1068 →	-0.231	-2.321	.010	.001	3	1
UCEC	eIF4E →	+0.196	+3.598	.009	.001	3	1
UCEC	eIF4G →	+0.308	+3.584	.005	.002	3	1
UCEC	A-Raf_pS299 →	-0.122	-1.700	.004	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PDCD4 by C1orf116 expression — UCEC

Explore this box plot interactively →