C1orf112

Across TCGA pan-cancer cohorts, C1orf112 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C1orf112 data layer compared with 30 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C1orf112 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated C1orf112 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, KIRC, and OV are the cancer types where C1orf112 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.522	.007	32	view →
KIRC	OS	Median	All	0.057	0.881	<.001	12	view →
OV	OS	Median	IV	0.007	0.760	<.001	12	view →
BLCA	OS	Median	IV	0.239	0.602	.040	3	view →
LIHC	DFS	Median	All	0.043	0.527	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C1orf112–UCEC (DFS)

Open the UCEC breakdown →