C1orf112

Across TCGA pan-cancer cohorts, C1orf112 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of C1orf112’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C1orf112 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C1orf112 is over-expressed in tumor.

HNSC, LSCC, and LUAD are the cancer types where C1orf112 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf112 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.615	.015	5	view →
LSCC	Male	II,III,IV	+0.586	<.001	5	view →
LUAD	All	III,IV	+0.610	.005	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

C1orf112–HNSC

Open the HNSC breakdown →