C1orf112

Across TCGA patient cohorts, C1orf112 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf112-associated genes across cancer lineages are Notch1, TFRC, and 14-3-3_beta. Each is linked with C1orf112 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf112-to-partner and partner-to-C1orf112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by C1orf112-low versus C1orf112-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf112→partner) and Y-score (partner→C1orf112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.115	+1.424	.008	.027	3	2
UCEC	TFRC →	+0.333	+1.874	.043	.049	3	2
UCEC	14-3-3_beta →	-0.081	-1.558	.009	.032	3	1
UCEC	eEF2 →	+0.246	+1.906	.027	.014	3	1
UCEC	EGFR_pY1068 →	-0.238	-2.662	.002	<.001	3	1
UCEC	EGFR →	-0.131	-1.415	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Notch1 by C1orf112 expression — UCEC

Explore this box plot interactively →