C1orf112

Across TCGA cell cohorts, C1orf112 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C1orf112-associated genes across cancer lineages are GHRH, GABRA6, and SPEM3. Each is linked with C1orf112 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf112-to-partner and partner-to-C1orf112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by C1orf112-low versus C1orf112-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf112→partner) and Y-score (partner→C1orf112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
LARGE_INTESTINE	GABRA6 →	+0.372	+3.345	<.001	.007	3	1
LARGE_INTESTINE	SPEM3 →	+0.013	+3.347	<.001	.005	3	1
OVARY	KRTAP5-6 →	+0.142	+3.700	<.001	.008	3	1
OVARY	IFNA17 →	+0.012	+4.222	<.001	.006	3	1
OVARY	GUCA1A →	+0.034	+3.862	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

GHRH by C1orf112 expression — OESOPHAGUS

Explore this box plot interactively →