C1orf109

Across TCGA pan-cancer cohorts, C1orf109 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C1orf109 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C1orf109 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C1orf109 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where C1orf109 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.809	0.316	.001	46	view →
LUAD	DFS	Median	II,III,IV	0.713	1.000	.010	12	view →
LSCC	OS	Tertile	All	0.870	0.644	.016	6	view →
PDAC	OS	Median	II,III,IV	0.759	0.967	.010	6	view →
GBM	OS	Tertile	All	0.722	0.410	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C1orf109–CCRCC (DFS)

Open the CCRCC breakdown →