C1orf109

Across TCGA patient cohorts, C1orf109 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf109-associated genes across cancer lineages are Notch1, JNK2, and Ku80. Each is linked with C1orf109 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf109-to-partner and partner-to-C1orf109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by C1orf109-low versus C1orf109-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf109→partner) and Y-score (partner→C1orf109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.254	+3.179	<.001	.010	3	2
UCEC	JNK2 →	+0.330	+2.817	.001	.036	3	1
UCEC	Ku80 →	+0.246	+2.183	.046	.035	3	1
UCEC	PCNA →	+0.274	+3.000	.015	.036	3	1
UCEC	PDCD4 →	-0.659	-2.999	.007	.035	3	1
UCEC	AMPK_pT172 →	+0.427	+2.183	.047	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by C1orf109 expression — UCEC

Explore this box plot interactively →