C1orf105

Across TCGA pan-cancer cohorts, C1orf105 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C1orf105 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher C1orf105 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C1orf105 expression acts as an unfavorable survival marker.

ESCA, HNSC, and LUAD are the cancer types where C1orf105 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	24	view →
HNSC	OS	Median	II,III,IV	0.021	0.712	<.001	24	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	12	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C1orf105–ESCA (OS)

Open the ESCA breakdown →