C1orf100

Across TCGA patient cohorts, C1orf100 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf100-associated genes across cancer lineages are EGFR_pY1068, Gab2, and JNK_pT183_Y185. Each is linked with C1orf100 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf100-to-partner and partner-to-C1orf100 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C1orf100-low versus C1orf100-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf100→partner) and Y-score (partner→C1orf100) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.266	-2.321	.035	.035	3	1
UCEC	Gab2 →	+0.505	+3.459	.004	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.202	-3.446	.017	.005	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.612	-3.446	.006	.005	3	1
UCEC	Shc_pY317 →	-0.250	-3.169	.001	.019	3	1
UCEC	VHL →	-1.100	-3.169	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by C1orf100 expression — UCEC

Explore this box plot interactively →