C1RL

Across TCGA pan-cancer cohorts, C1RL mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C1RL data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher C1RL mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C1RL expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, UCEC, and GBM are the cancer types where C1RL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.827	1.000	.001	53	view →
UCEC	OS	Median	III,IV	0.494	1.000	.016	40	view →
GBM	OS	Median	All	0.277	0.536	.009	14	view →
CCRCC	OS	Median	All	1.000	0.909	.019	8	view →
LSCC	OS	Quartile	All	0.913	1.000	.026	8	view →
PDAC	OS	Tertile	III,IV	0.264	0.739	.035	2	view →
HNSC	OS	Quartile	All	0.944	1.000	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C1RL–LUAD (OS)

Open the LUAD breakdown →