C1RL

Across TCGA patient cohorts, C1RL protein abundance is significantly associated with the RNA expression of many other genes, with 14,144 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C1RL-associated genes across cancer lineages are LYVE1, MCM4, and AOC3. Each is linked with C1RL in more than 5 cancer types. Because this analysis shows association rather than direction, both C1RL-to-partner and partner-to-C1RL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1RL versus LYVE1 in BRCA, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1RL→partner) and Y-score (partner→C1RL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LYVE1 →	+1.465	+0.608	<.001	<.001	3	6
LSCC	MCM4 →	-0.684	-0.288	<.001	<.001	3	5
BRCA	AOC3 →	+0.952	+0.444	<.001	<.001	3	5
CCRCC	COLEC12 →	+1.011	+0.531	<.001	<.001	3	5
BRCA	ZNF208 →	+0.769	+0.472	<.001	<.001	3	5
HNSC	MAGI2-AS3 →	+0.678	+0.236	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,144 associations by consensus.

C1RL vs LYVE1 — BRCA

Explore this scatter interactively →