C1RL

Across TCGA patient cohorts, C1RL mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1RL-associated genes across cancer lineages are Rab25, Annexin-1, and Cyclin-B1. Each is linked with C1RL in more than 1 cancer types. Because this analysis shows association rather than direction, both C1RL-to-partner and partner-to-C1RL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by C1RL-low versus C1RL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1RL→partner) and Y-score (partner→C1RL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.366	-3.000	.028	.036	3	1
UCEC	Annexin-1 →	+0.665	+3.019	.011	.019	3	1
UCEC	Cyclin-B1 →	+0.629	+2.321	.025	.035	3	1
SKCM	4E-BP1_pT37_T46 →	+0.494	+3.000	.032	.036	2	1
UCEC	Rab11 →	-0.197	-3.459	.006	.005	1	1
UCEC	TAZ →	-0.161	-2.321	.023	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Rab25 by C1RL expression — UCEC

Explore this box plot interactively →